Corticosteroids for community-acquired pneumonia: a critical view of the evidence.
نویسنده
چکیده
There has been little progress in the management of CAP since the widespread introduction of antibiotics in the 1950s, with no new classes of drugs licensed specifically for CAP and little progress in reducing mortality. The focus of international guidelines for CAP have been on “doing the simple things well”, since early antibiotic administration, appropriate fluid resuscitation, early mobilisation and guideline-concordant antibiotics have been associated with improved outcomes, albeit with low-quality evidence [3–5].
منابع مشابه
Corticosteroids in severe community-acquired pneumonia: the path we choose depends on where we want to get
Severe community-acquired pneumonia is a major cause of admission to intensive care units and its mortality rates remain exceedingly high. In the search for adjunctive therapies, clinicians who were encouraged by available, though limited, evidence prescribed steroids in most patients with severe sepsis or septic shock, including those with community-acquired pneumonia. Current evidence demonst...
متن کاملThe role of corticosteroids in severe community-acquired pneumonia: a systematic review
INTRODUCTION The purpose of this review was to evaluate the impact of corticosteroids on the outcomes of patients with severe community-acquired pneumonia (CAP). METHODS We performed a systematic MEDLINE, Cochrane database, and CINAHL search (1966 to November 2007) to identify full-text publications that evaluated the use of corticosteroids in CAP. RESULTS An initial literature search yield...
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The use of corticosteroids for the treatment of community-acquired pneumonia has been reported for almost 50 years. A recent systematic analysis of the relevant literature suggested that corticosteroids reduce the critical illness associated with community-acquired pneumonia. There is little doubt that a prolonged administration of a moderate dose of corticosteroids may alleviate the systemic i...
متن کاملHyperglycemia and Red Cell Distribution Width for Prediction of Mortality in Preschool Children with Community Acquired Pneumonia (CAP)
Background Community acquired pneumonia (CAP) is a major infectious cause of mortality in preschool children especially in developing countries. Red Cell Distribution Width (RDW) has been associated with poor outcomes of CAP. We aimed to determine whether admission stress hyperglycemia and RDW can predict mortality in preschool children with CAP for early identification of patients at risk of ...
متن کاملCorticosteroid treatment of severe community-acquired pneumonia.
OBJECTIVE To assess the evidence for adjunctive corticosteroids for severe community-acquired pneumonia (CAP). DATA SOURCES MEDLINE (1966-February 2007) and EMBASE (1980-February 2007) were searched to identify English- and French-language publications that evaluated the use of corticosteroids for CAP in adults. Major search terms included community-acquired pneumonia, intensive care unit, st...
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عنوان ژورنال:
- The European respiratory journal
دوره 48 4 شماره
صفحات -
تاریخ انتشار 2016